Download PLR Content Directory Mississippi: 2016

Wednesday, 28 September 2016

Delhistine D

Generic Name: pheniramine/ pyrilamine/ phenyltoloxamine/ phenylpropanolamine (fen IR a meen/pie RILL a meen/fen ill toe LOX a meen/fen ill proe pa NOLE a meen)

Brand Names: Delhist D, Delhistine D, Histine-D, Iohist D, KG-Hist D, Liqui-Histine-D, Metahistine D, Multihist D, Multihistamine-D, Poly-D, Poly-Histine-D, Prohistine-D, Trihist-D

What is Delhistine D (pheniramine/ pyrilamine/ phenyltoloxamine/ phenylpropanolamine)?

Pheniramine, pyrilamine, and phenyltoloxamine are antihistamines. They block the effects of the naturally occurring chemical histamine in the body. Pheniramine, pyrilamine, and phenyltoloxamine prevent sneezing; itchy, watery eyes and nose; and other symptoms of allergies and hay fever.

Phenylpropanolamine is a decongestant. It constricts (shrinks) blood vessels (veins and arteries). This reduces the blood flow to certain areas and allows nasal and respiratory (breathing) passages to open up.

Pheniramine/pyrilamine/phenyltoloxamine/phenylpropanolamine is used to treat nasal congestion and sinusitis (inflammation of the sinuses) associated with allergies, hay fever, and the common cold.

Phenylpropanolamine, an ingredient in this product, has been associated with an increased risk of hemorrhagic stroke (bleeding into the brain or into tissue surrounding the brain) in women. Men may also be at risk. Although the risk of hemorrhagic stroke is low, the U.S. Food and Drug Administration (FDA) recommends that consumers not use any products that contain phenylpropanolamine.

Pheniramine/pyrilamine/phenyltoloxamine/phenylpropanolamine may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about Delhistine D (pheniramine/ pyrilamine/ phenyltoloxamine/ phenylpropanolamine)?

Use caution when driving, operating machinery, or performing other hazardous activities. Pheniramine/pyrilamine/phenyltoloxamine/phenylpropanolamine may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities. Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while taking this medication.

Do not take more of this medication than is recommended. If your symptoms do not improve, or if they worsen, talk to your doctor.

Who should not take Delhistine D (pheniramine/ pyrilamine/ phenyltoloxamine/ phenylpropanolamine)?

Do not take pheniramine/pyrilamine/phenyltoloxamine/phenylpropanolamine if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects.

Before taking this medication, tell your doctor if you have

kidney disease,

liver disease,

diabetes,

glaucoma,

any type of heart disease or high blood pressure,

thyroid disease,

emphysema or chronic bronchitis, or

difficulty urinating or an enlarged prostate.

You may not be able to take pheniramine/pyrilamine/phenyltoloxamine/phenylpropanolamine, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.

Pheniramine/pyrilamine/phenyltoloxamine/phenylpropanolamine is in the FDA pregnancy category B. This means that it is unlikely to harm an unborn baby. Do not take this medication without first talking to your doctor if you are pregnant. Pheniramine/pyrilamine/phenyltoloxamine/phenylpropanolamine passes into breast milk and may harm a nursing infant. Do not take this medication without first talking to your doctor if you are breast-feeding a baby. If you are over 65 years of age, you may be more likely to experience side effects from pheniramine/pyrilamine/phenyltoloxamine/phenylpropanolamine. You may require a lower dose of this medication. Read the package label for directions or consult your doctor or pharmacist before treating a child with this medication. Children are more susceptible than adults to the effects of medicines and may have unusual reactions.

How should I take Delhistine D (pheniramine/ pyrilamine/ phenyltoloxamine/ phenylpropanolamine)?

Take pheniramine/pyrilamine/phenyltoloxamine/phenylpropanolamine exactly as directed. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Take each dose with a full glass of water. Do not crush, chew, or break the long-acting or sustained-release forms of this medication. Swallow them whole. If you are unsure about the formulation of the medicine, ask your pharmacist for help.

If you cannot swallow the tablets or capsules, look for a liquid form of this medication.

To ensure that you get a correct dose, measure the liquid form of pheniramine/pyrilamine/phenyltoloxamine/phenylpropanolamine with a special dose-measuring spoon or cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist where you can get one.

Do not take more of this medication than is recommended. An overdose can cause serious harm.

Do not take pheniramine/pyrilamine/phenyltoloxamine/phenylpropanolamine for longer than 7 days in a row. If your symptoms do not improve, if they get worse, or if you have a fever, talk to your doctor.

Store pheniramine/pyrilamine/phenyltoloxamine/phenylpropanolamine at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and take only the next regularly scheduled dose. Do not take a double dose of this medication.

What happens if I overdose?

Seek emergency medical attention.

Symptoms of a pheniramine/pyrilamine/phenyltoloxamine/phenylpropanolamine overdose include a dry mouth, large pupils, flushing, nausea, and vomiting.

What should I avoid while taking Delhistine D (pheniramine/ pyrilamine/ phenyltoloxamine/ phenylpropanolamine)?

Delhistine D (pheniramine/ pyrilamine/ phenyltoloxamine/ phenylpropanolamine) side effects

Serious side effects are unlikely to occur. Stop taking pheniramine/pyrilamine/phenyltoloxamine/phenylpropanolamine and seek emergency medical attention if you experience an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives).

Other, less serious side effects may be more likely to occur. Continue to take pheniramine/pyrilamine/phenyltoloxamine/phenylpropanolamine and talk to your doctor or try another similar medication if you experience

dryness of the eyes, nose, and mouth;

drowsiness or dizziness;

blurred vision;

difficulty urinating; or

excitation in children.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect Delhistine D (pheniramine/ pyrilamine/ phenyltoloxamine/ phenylpropanolamine)?

Do not take other over-the-counter cough, cold, allergy, diet, or sleep aids while taking pheniramine/pyrilamine/phenyltoloxamine/phenylpropanolamine without first talking to your doctor or pharmacist. Other medications may also contain pheniramine, pyrilamine, phenyltoloxamine, phenylpropanolamine, or other similar drugs. You may accidentally take too much of these medicines.

Pheniramine/pyrilamine/phenyltoloxamine/phenylpropanolamine may increase the effects of other drugs that cause drowsiness, including antidepressants, alcohol, other antihistamines, pain relievers, anxiety medicines, seizure medicines, and muscle relaxants. Dangerous sedation, dizziness, or drowsiness may occur if pheniramine/pyrilamine/phenyltoloxamine/phenylpropanolamine is taken with any of these medications.

Drugs other than those listed here may also interact with pheniramine/pyrilamine/phenyltoloxamine/phenylpropanolamine. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including herbal products.

More Delhistine D resources

Delhistine D Drug Interactions
Delhistine D Support Group
0 Reviews for Delhistine D - Add your own review/rating

Compare Delhistine D with other medications

Allergies
Eye Dryness/Redness
Eye Redness/Itching
Hay Fever
Nasal Congestion
Rhinorrhea
Sinusitis
Upper Respiratory Tract Infection

Where can I get more information?

Your pharmacist has additional information about pheniramine/pyrilamine/phenyltoloxamine/phenylpropanolamine written for health professionals that you may read.

What does my medication look like?

Pheniramine/pyrilamine/phenyltoloxamine/phenylpropanolamine is available with a prescription under the brand names Poly-Histine-D (capsules and elixir) and Liqui-Histine Elixir. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

Ophthalmyvet

Ophthalmyvet may be available in the countries listed below.

In some countries, this medicine may only be approved for veterinary use.

Ingredient matches for Ophthalmyvet

Bacitracin

Bacitracin is reported as an ingredient of Ophthalmyvet in the following countries:

Switzerland

Neomycin

Neomycin sulfate (a derivative of Neomycin) is reported as an ingredient of Ophthalmyvet in the following countries:

Switzerland

Polymyxin B

Polymyxin B sulfate (a derivative of Polymyxin B) is reported as an ingredient of Ophthalmyvet in the following countries:

Switzerland

International Drug Name Search

Deconamine SR Controlled-Release Capsules

Pronunciation: klor-fen-IHR-ah-meen/sue-do-eh-FED-rin
Generic Name: Chlorpheniramine/Pseudoephedrine
Brand Name: Generic only. No brands available.

Deconamine SR Controlled-Release Capsules are used for:

Relieving symptoms of sinus congestion, sinus pressure, runny nose, and sneezing due to colds, upper respiratory infections, and allergies. It may also be used for other conditions as determined by your doctor.

Deconamine SR Controlled-Release Capsules are an antihistamine and decongestant combination. The antihistamine works by blocking the action of histamine, which helps reduce symptoms such as watery eyes and sneezing. The decongestant promotes sinus and nasal drainage, relieving congestion and pressure.

Do NOT use Deconamine SR Controlled-Release Capsules if:

you are allergic to any ingredient in Deconamine SR Controlled-Release Capsules

you have severe high blood pressure, severe heart blood vessel disease, rapid heartbeat, or severe heart problems

you take sodium oxybate (GHB) or if you have taken furazolidone or a monoamine oxidase inhibitor (MAOI) (eg, phenelzine) within the last 14 days

Contact your doctor or health care provider right away if any of these apply to you.

Before using Deconamine SR Controlled-Release Capsules:

Some medical conditions may interact with Deconamine SR Controlled-Release Capsules. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have a fast, slow, or irregular heartbeat

if you have a history of asthma, lung problems (eg, emphysema), adrenal gland problems (eg, adrenal gland tumor), heart problems, high blood pressure, diabetes, heart blood vessel problems, stroke, glaucoma, a blockage of your stomach or intestines, ulcers, a blockage of your bladder, trouble urinating, an enlarged prostate, seizures, or an overactive thyroid

Some MEDICINES MAY INTERACT with Deconamine SR Controlled-Release Capsules. Tell your health care provider if you are taking any other medicines, especially any of the following:

Beta-blockers (eg, propranolol), catechol-O-methyltransferase (COMT) inhibitors (eg, tolcapone), furazolidone, indomethacin, MAOIs (eg, phenelzine), sodium oxybate (GHB), or tricyclic antidepressants (eg, amitriptyline) because they may increase the risk of Deconamine SR Controlled-Release Capsules's side effects

Digoxin or droxidopa because the risk of irregular heartbeat or heart attack may be increased

Bromocriptine or hydantoins (eg, phenytoin) because the risk of their side effects may be increased by Deconamine SR Controlled-Release Capsules

Guanethidine, guanadrel, mecamylamine, methyldopa, or reserpine because their effectiveness may be decreased by Deconamine SR Controlled-Release Capsules

This may not be a complete list of all interactions that may occur. Ask your health care provider if Deconamine SR Controlled-Release Capsules may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Deconamine SR Controlled-Release Capsules:

Use Deconamine SR Controlled-Release Capsules as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Take Deconamine SR Controlled-Release Capsules by mouth with or without food.

Swallow Deconamine SR Controlled-Release Capsules whole. Do not break, crush, or chew before swallowing.

If you miss a dose of Deconamine SR Controlled-Release Capsules, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Deconamine SR Controlled-Release Capsules.

Important safety information:

Deconamine SR Controlled-Release Capsules may cause dizziness, drowsiness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Deconamine SR Controlled-Release Capsules with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.

Do not take diet or appetite control medicines while you are taking Deconamine SR Controlled-Release Capsules without checking with you doctor.

Deconamine SR Controlled-Release Capsules has pseudoephedrine in it. Before you start any new medicine, check the label to see if it has pseudoephedrine in it too. If it does or if you are not sure, check with your doctor or pharmacist.

Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.

If your symptoms do not get better within 5 to 7 days or if they get worse, check with your doctor.

Deconamine SR Controlled-Release Capsules may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Deconamine SR Controlled-Release Capsules. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.

Deconamine SR Controlled-Release Capsules may interfere with skin allergy tests. If you are scheduled for a skin test, talk to your doctor. You may need to stop taking Deconamine SR Controlled-Release Capsules for a few days before the tests.

Tell your doctor or dentist that you take Deconamine SR Controlled-Release Capsules before you receive any medical or dental care, emergency care, or surgery.

Use Deconamine SR Controlled-Release Capsules with caution in the ELDERLY; they may be more sensitive to its effects.

Caution is advised when using Deconamine SR Controlled-Release Capsules in CHILDREN; they may be more sensitive to its effects.

PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Deconamine SR Controlled-Release Capsules while you are pregnant. It is not known if Deconamine SR Controlled-Release Capsules are found in breast milk. Do not breast-feed while taking Deconamine SR Controlled-Release Capsules.

Possible side effects of Deconamine SR Controlled-Release Capsules:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; diarrhea; dizziness; drowsiness; excitability; headache; loss of appetite; nausea; nervousness or anxiety; trouble sleeping; upset stomach; vomiting; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); difficulty urinating or inability to urinate; fast or irregular heartbeat; hallucinations; seizures; severe dizziness, lightheadedness, or headache; tremor; vision changes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Deconamine SR side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include blurred vision; confusion; hallucinations; seizures; severe dizziness, lightheadedness, or headache; severe drowsiness; unusually fast, slow, or irregular heartbeat; vomiting.

Proper storage of Deconamine SR Controlled-Release Capsules:

Store Deconamine SR Controlled-Release Capsules at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Deconamine SR Controlled-Release Capsules out of the reach of children and away from pets.

General information:

If you have any questions about Deconamine SR Controlled-Release Capsules, please talk with your doctor, pharmacist, or other health care provider.

Deconamine SR Controlled-Release Capsules are to be used only by the patient for whom it is prescribed. Do not share it with other people.

If your symptoms do not improve or if they become worse, check with your doctor.

Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Deconamine SR Controlled-Release Capsules. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

More Deconamine SR resources

Deconamine SR Side Effects (in more detail)
Deconamine SR Use in Pregnancy & Breastfeeding
Drug Images
Deconamine SR Drug Interactions
Deconamine SR Support Group
5 Reviews for Deconamine SR - Add your own review/rating

Compare Deconamine SR with other medications

Hay Fever
Sinusitis

Tuesday, 27 September 2016

Dec-Chlorphen

Generic Name: chlorpheniramine and phenylephrine (KLOR fen IR a meen and FEN il EFF rin)

Brand Names: Actifed Cold & Allergy, Allan Tannate Pediatric, Allerest PE, AlleRx, BP Allergy JR, C Phen, Cardec, Ceron, Chlor-Mes Jr, ChlorTan D, Cold & Allergy Relief, CP Dec, Dallergy Drops, Dallergy-JR, Dec-Chlorphen, Ed A-Hist, Ed ChlorPed D, Histadec, Nasohist Pediatric, NoHist, Ny-Tannic, PD-Hist D, PD-Hist D Drops, PediaTan D, Phenchlor Tannate Pediatric, R-Tanna, Relera, Rinate Pediatric, Rondec, Rondex, Rynatan, Rynatan Pediatric, Sildec-PE, Sinus & Allergy Maximum Strength, Sinus & Allergy PE, Sonahist, Sudafed PE Sinus & Allergy, Tanahist-D, Triaminic Cold & Allergy

What is Dec-Chlorphen (chlorpheniramine and phenylephrine)?

Chlorpheniramine is an antihistamine that reduces the natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Phenylephrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).

The combination of chlorpheniramine and phenylephrine is used to treat symptoms of the common cold or seasonal allergies, including sneezing, runny or stuffy nose, and itchy, watery eyes.

Chlorpheniramine and phenylephrine may also be used for purposes not listed in this medication guide.

What is the most important information I should know about Dec-Chlorphen (chlorpheniramine and phenylephrine)?

There are many brands and forms of this medication available and not all brands are listed on this leaflet.

Do not use chlorpheniramine and phenylephrine if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects. You should not use this medication if you are allergic to chlorpheniramine or phenylephrine, or if you have severe high blood pressure or coronary artery disease, narrow-angle glaucoma, a stomach ulcer, or if you are unable to urinate.

Do not use this medication during an asthma attack.

This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Drinking alcohol can increase certain side effects of chlorpheniramine and phenylephrine. Older adults may be more likely to have side effects from this medicine. Do not give this medication to a child younger than 4 years old. Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children.

Talk with your doctor if your symptoms do not improve after 7 days of treatment, or if you have a fever with a headache, cough, or skin rash.

What should I discuss with my healthcare provider before taking Dec-Chlorphen (chlorpheniramine and phenylephrine)?

severe or uncontrolled high blood pressure;

severe coronary artery disease;

narrow angle glaucoma;

a stomach ulcer;

if you are unable to urinate; or

if you are having an asthma attack.

Ask a doctor or pharmacist if it is safe for you to take this medication if you have:

kidney disease;

liver disease;

diabetes;

glaucoma;

circulation problems;

heart disease or high blood pressure;

overactive thyroid;

a seizure disorder such as epilepsy;

asthma, emphysema or chronic bronchitis; or

urination problems or an enlarged prostate.

It is not known whether chlorpheniramine and phenylephrine is harmful to an unborn baby. Do not take this medication with a doctor's advice if you are pregnant. It is not known whether chlorpheniramine and phenylephrine passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Older adults may be more likely to have side effects from this medicine.

Artificially sweetened liquid cold medicine may contain phenylalanine. If you have phenylketonuria (PKU), check the medication label to see if the product contains phenylalanine.

How should I take Dec-Chlorphen (chlorpheniramine and phenylephrine)?

Use exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Cold medicine is usually taken only for a short time until your symptoms clear up.

Do not give this medication to a child younger than 4 years old. Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children. Do not crush, chew, break, or open an extended-release tablet or capsule. Swallow it whole. Breaking or opening the pill may cause too much of the drug to be released at one time.

The chewable tablet must be chewed before swallowing.

Measure liquid medicine with a special dose-measuring spoon or medicine cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

Talk with your doctor if your symptoms do not improve after 7 days of treatment, or if you have a fever with a headache, cough, or skin rash.

This medication can cause unusual results with allergy skin tests. Tell any doctor who treats you that you are taking an antihistamine.

If you need surgery, tell the surgeon ahead of time if you have taken a cold medicine within the past few days.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Since cold medicine is taken as needed, you may not be on a dosing schedule. If you are taking the medication regularly, take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include some of the serious side effects listed in this medication guide.

What should I avoid while taking Dec-Chlorphen (chlorpheniramine and phenylephrine)?

This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Drinking alcohol can increase certain side effects of chlorpheniramine and phenylephrine. Ask a doctor or pharmacist before using any other cold, allergy, or sleep medicine. Chlorpheniramine and phenylephrine are contained in many combination medicines. Taking certain products together can cause you to get too much of a certain drug. Check the label to see if a medicine contains an antihistamine or decongestant.

Avoid taking this medication if you also take diet pills, caffeine pills, or other stimulants (such as ADHD medications). Taking a stimulant together with a decongestant can increase your risk of unpleasant side effects.

Dec-Chlorphen (chlorpheniramine and phenylephrine) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using this medication and call your doctor at once if you have a serious side effect such as:

fast or pounding heartbeats;

confusion, hallucinations, unusual thoughts or behavior;

severe dizziness, anxiety, restless feeling, nervousness;

urinating less than usual or not at all;

easy bruising or bleeding, unusual weakness; or

seizure (black-out or convulsions).

Less serious side effects may include:

blurred vision;

dry nose or mouth;

nausea, stomach pain, constipation, loss of appetite;

dizziness, drowsiness;

problems with memory or concentration;

ringing in your ears; or

feeling restless or excited (especially in children).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1 800 FDA 1088.

What other drugs will affect Dec-Chlorphen (chlorpheniramine and phenylephrine)?

Before using this medication, tell your doctor if you regularly use other medicines that make you sleepy (such as other cold or allergy medicine, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety). They can add to sleepiness caused by chlorpheniramine.

Tell your doctor about all other medications you use, especially:

mecamylamine (Inversine);

methyldopa (Aldomet);

reserpine;

a beta-blocker such as atenolol (Tenormin, Tenoretic), carvedilol (Coreg), labetalol (Normodyne, Trandate), metoprolol (Lopressor, Toprol), nadolol (Corgard), propranolol (Inderal, InnoPran), sotalol (Betapace), and others;

a barbiturate such as butabarbital (Butisol), secobarbital (Seconal), pentobarbital (Nembutal), or phenobarbital (Solfoton); or

an antidepressant such as amitriptyline (Elavil, Vanatrip), doxepin (Sinequan), nortriptyline (Pamelor), and others.

This list is not complete and other drugs may interact with chlorpheniramine and phenylephrine. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More Dec-Chlorphen resources

Dec-Chlorphen Side Effects (in more detail)
Dec-Chlorphen Use in Pregnancy & Breastfeeding
Dec-Chlorphen Drug Interactions
Dec-Chlorphen Support Group
0 Reviews for Dec-Chlorphen - Add your own review/rating

AlleRx Suspension MedFacts Consumer Leaflet (Wolters Kluwer)

Cardec Drops MedFacts Consumer Leaflet (Wolters Kluwer)

Dallergy-JR Sustained-Release Capsules MedFacts Consumer Leaflet (Wolters Kluwer)

Ny-Tannic MedFacts Consumer Leaflet (Wolters Kluwer)

Relera Controlled-Release Tablets MedFacts Consumer Leaflet (Wolters Kluwer)

Rondec MedFacts Consumer Leaflet (Wolters Kluwer)

Rynatan Prescribing Information (FDA)

Sonahist Prescribing Information (FDA)

Compare Dec-Chlorphen with other medications

Cold Symptoms
Hay Fever

Where can I get more information?

Your pharmacist can provide more information about chlorpheniramine and phenylephrine.

See also: Dec-Chlorphen side effects (in more detail)

Demser

Pronunciation: meh-TYE-row-seen
Generic Name: Metyrosine
Brand Name: Demser

Demser is used for:

Decreasing the amount of certain chemicals (catecholamines) in the body caused by a type of adrenal gland tumor (pheochromocytoma). It may be used either as a pretreatment before surgery or for the long-term treatment of symptoms associated with this disorder.

Demser is a catecholamine synthesis inhibitor. It works by reducing the amount of catecholamines in the body.

Do NOT use Demser if:

you are allergic to any ingredient in Demser

Contact your doctor or health care provider right away if any of these apply to you.

Before using Demser:

Some medical conditions may interact with Demser. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, plan to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you drink alcohol or take medicines that can cause drowsiness

Some MEDICINES MAY INTERACT with Demser. Tell your health care provider if you are taking any other medicines, especially any of the following:

Haloperidol or phenothiazines (eg, chlorpromazine) because the risk of extrapyramidal effects (eg, involuntary muscle movements of the head, neck, or limbs; speech difficulty; tremors) may be increased when taking Demser

Medicines for sleep (eg, zolpidem), medicines for anxiety (eg, diazepam), or tranquilizers (eg, olanzapine) because severe drowsiness may occur

This may not be a complete list of all interactions that may occur. Ask your health care provider if Demser may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Demser:

Use Demser as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Demser may be taken with or without food.

Drink plenty of fluids (at least 8 to 10 glasses per day) while taking Demser.

If you miss a dose of Demser, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Demser.

Important safety information:

Demser may cause drowsiness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Demser. Using Demser alone, with certain other medicines, or with alcohol may lessen your ability to drive or to perform other potentially dangerous tasks.

Avoid drinking alcohol or taking other medications that cause drowsiness (eg, sedatives, tranquilizers) while taking Demser. Demser will add to the effects of alcohol and other depressants. Ask your pharmacist if you have questions about which medicines are depressants.

Before you have any medical or dental treatments or surgery, tell the doctor or dentist that you are taking Demser.

Demser is not recommended for use in CHILDREN younger than 12 years of age. Safety and effectiveness in this age group have not been confirmed.

PREGNANCY and BREAST-FEEDING: If you are pregnant or plan on becoming pregnant, discuss with your doctor the benefits and risks of using Demser during pregnancy. It is unknown if Demser is excreted in breast milk. If you are or will be breast-feeding while you are using Demser, check with your doctor or pharmacist to discuss the risks to your baby.

Possible side effects of Demser:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Moderate to severe drowsiness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); anxiety; confusion; crystals in the urine; depression; diarrhea; difficulty speaking; disorientation; drooling; hallucinations; painful urination; speech difficulty; swelling of the arms, legs, ankles, or feet; tremor.

See also: Demser side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include diarrhea; dry mouth; severe drowsiness; tightening of the jaw; tremor of the hands and body.

Proper storage of Demser:

Store Demser at room temperature between 68 and 77 degrees F (20 and 25 degrees C) away from heat, moisture, and light. Do not store in the bathroom. Keep Demser out of the reach of children and away from pets.

General information:

If you have any questions about Demser, please talk with your doctor, pharmacist, or other health care provider.

Demser is to be used only by the patient for whom it is prescribed. Do not share it with other people.

If your symptoms do not improve or if they become worse, check with your doctor.

Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Demser. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

More Demser resources

Demser Side Effects (in more detail)
Demser Use in Pregnancy & Breastfeeding
Drug Images
Demser Drug Interactions
Demser Support Group
0 Reviews for Demser - Add your own review/rating

Demser Prescribing Information (FDA)

Demser Concise Consumer Information (Cerner Multum)

Demser Advanced Consumer (Micromedex) - Includes Dosage Information

Compare Demser with other medications

Pheochromocytoma

Zitrocin

Zitrocin may be available in the countries listed below.

Ingredient matches for Zitrocin

Azithromycin

Azithromycin is reported as an ingredient of Zitrocin in the following countries:

Tunisia

Azithromycin dihydrate (a derivative of Azithromycin) is reported as an ingredient of Zitrocin in the following countries:

Czech Republic

Hungary

Slovakia

Slovenia

International Drug Name Search

Dexchlorpheniramine/Phenylephrine/Methscopolamine Solution

Pronunciation: DEX-klor-fen-IR-a-meen/FEN-il-EF-rin/METH-skoe-POL-a-meen
Generic Name: Dexchlorpheniramine/Phenylephrine/Methscopolamine
Brand Name: Examples include Dexphen M and Extendryl

Dexchlorpheniramine/Phenylephrine/Methscopolamine Solution is used for:

Relieving nasal and chest congestion, sneezing, runny nose, and itchy, watery eyes due to colds, flu, or allergies. It is also used to make a dry cough more productive and less frequent. It may also be used for other conditions as determined by your doctor.

Dexchlorpheniramine/Phenylephrine/Methscopolamine Solution is an antihistamine, decongestant, and anticholinergic combination. The antihistamine works by blocking the action of histamine, which helps reduce symptoms, such as watery eyes and sneezing. The decongestant works by constricting blood vessels and reducing swelling in the nasal passages. The anticholinergic works by drying mucous membranes in the nose and airway.

Do NOT use Dexchlorpheniramine/Phenylephrine/Methscopolamine Solution if:

you are allergic to any ingredient in Dexchlorpheniramine/Phenylephrine/Methscopolamine Solution

you are pregnant or breast-feeding

you are taking droxidopa, furazolidone, sodium oxybate (GHB), or a monoamine oxidase inhibitor (MAOI) (eg, phenelzine), or if you have taken an MAOI within the past 14 days

you have severe heart blood vessel problems, severe high blood pressure, narrow-angle glaucoma, difficulty urinating due to enlarged prostate, peptic ulcer, or uncontrolled bleeding

you are having an asthma attack

the patient is a newborn or infant

Contact your doctor or health care provider right away if any of these apply to you.

Before using Dexchlorpheniramine/Phenylephrine/Methscopolamine Solution:

Some medical conditions may interact with Dexchlorpheniramine/Phenylephrine/Methscopolamine Solution. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you are taking or have taken medicine for high blood pressure or depression in the last 14 days, or if you take potassium chloride

if you have bladder blockage, blood vessel problems (eg, hardening of the arteries), diabetes, an enlarged prostate, glaucoma or increased pressure in the eye, nerve problems, memory problems, heart problems (eg, fast or irregular heartbeat, heart failure), heart blood vessel problems, high blood pressure, kidney or liver problems, lung or breathing problems (eg asthma, sleep apnea), a hiatal hernia, esophagus problems, stomach or bowel problems (eg, ulcerative colitis), mental or mood problems (eg, depression), an adrenal gland tumor (pheochromocytoma), myasthenia gravis (muscle weakness), stomach or bowel problems (eg, constipation, inflammation, motility problems, blockage), trouble sleeping, or an overactive thyroid

if the patient is a child who has Down syndrome, spastic paralysis, or brain damage

if you have a history of alcohol abuse or if you are very ill

Some MEDICINES MAY INTERACT with Dexchlorpheniramine/Phenylephrine/Methscopolamine Solution. Tell your health care provider if you are taking any other medicines, especially any of the following:

Alkalizers (eg, calcium or magnesium antacids), alpha-blockers (eg, doxazosin), anesthetics (eg, chloroform, lidocaine), anticholinergics (eg, atropine, benztropine, dicyclomine), beta-blockers (eg, propranolol), carbonic anhydrase inhibitors (eg, acetazolamide), catechol-O-methyltransferase (COMT) inhibitors (eg, tolcapone), certain antidiarrheals (eg, bismuth subsalicylate), ergotamine, furazolidone, MAOIs (eg, phenelzine), sodium bicarbonate, or tricyclic antidepressants (eg, amitriptyline) because they may increase the risk of Dexchlorpheniramine/Phenylephrine/Methscopolamine Solution's side effects

Bromocriptine, certain stimulants (eg, doxapram, pseudoephedrine), digoxin, droxidopa, potassium chloride, or sodium oxybate (GHB) because the risk of their side effects may be increased by Dexchlorpheniramine/Phenylephrine/Methscopolamine Solution

Guanadrel, guanethidine, mecamylamine, methyldopa, reserpine, or other medicine for high blood pressure because their effectiveness may be decreased by Dexchlorpheniramine/Phenylephrine/Methscopolamine Solution

This may not be a complete list of all interactions that may occur. Ask your health care provider if Dexchlorpheniramine/Phenylephrine/Methscopolamine Solution may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Dexchlorpheniramine/Phenylephrine/Methscopolamine Solution:

Use Dexchlorpheniramine/Phenylephrine/Methscopolamine Solution as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Take Dexchlorpheniramine/Phenylephrine/Methscopolamine Solution by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.

Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.

Do not take Dexchlorpheniramine/Phenylephrine/Methscopolamine Solution at the same time as antacids, certain medicines for diarrhea (eg, attapulgite, bismuth, kaolin, pectin), or ketoconazole. Take these medicines 2 or 3 hours before or after taking Dexchlorpheniramine/Phenylephrine/Methscopolamine Solution.

If you miss a dose of Dexchlorpheniramine/Phenylephrine/Methscopolamine Solution and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Dexchlorpheniramine/Phenylephrine/Methscopolamine Solution.

Important safety information:

Dexchlorpheniramine/Phenylephrine/Methscopolamine Solution may cause drowsiness, dizziness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Dexchlorpheniramine/Phenylephrine/Methscopolamine Solution with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.

Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Dexchlorpheniramine/Phenylephrine/Methscopolamine Solution; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.

The risk of dizziness, nervousness, and trouble sleeping may be greater if you take Dexchlorpheniramine/Phenylephrine/Methscopolamine Solution in high doses or for a long time. Do NOT take more than the recommended dose without checking with your doctor.

If your cough or other symptoms persist for more than 1 week, if they come back, or if you also have fever, rash, or persistent headache, check with your doctor.

Tell your doctor or dentist that you take Dexchlorpheniramine/Phenylephrine/Methscopolamine Solution before you receive any medical or dental care, emergency care, or surgery.

Dexchlorpheniramine/Phenylephrine/Methscopolamine Solution may cause dry mouth. To relieve dry mouth, suck on sugarless hard candy or ice chips, chew sugarless gum, drink water, or use a saliva substitute.

Dexchlorpheniramine/Phenylephrine/Methscopolamine Solution may reduce sweating. Do not become overheated in hot weather or during exercise or other activities because heatstroke may occur.

Dexchlorpheniramine/Phenylephrine/Methscopolamine Solution may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Dexchlorpheniramine/Phenylephrine/Methscopolamine Solution. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.

Dexchlorpheniramine/Phenylephrine/Methscopolamine Solution may make your eyes more sensitive to sunlight. It may help to wear sunglasses.

Dexchlorpheniramine/Phenylephrine/Methscopolamine Solution has phenylephrine and an antihistamine in it. Before you start any new medicine, check the label to see if it has phenylephrine or an antihistamine in it too. If it does or if you are not sure, check with your doctor or pharmacist.

Diabetes patients - Dexchlorpheniramine/Phenylephrine/Methscopolamine Solution may affect your blood sugar. Check blood sugar levels closely and ask your doctor before adjusting the dose of your diabetes medicine.

Dexchlorpheniramine/Phenylephrine/Methscopolamine Solution may interfere with certain lab test results. Be sure your doctors and laboratory personnel know that you are taking Dexchlorpheniramine/Phenylephrine/Methscopolamine Solution.

Lab tests, including blood pressure and eye pressure, may be performed while you use Dexchlorpheniramine/Phenylephrine/Methscopolamine Solution. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Use Dexchlorpheniramine/Phenylephrine/Methscopolamine Solution with caution in the ELDERLY; they may be more sensitive to its effects, especially excitability, agitation, drowsiness, or confusion.

Dexchlorpheniramine/Phenylephrine/Methscopolamine Solution should be used with extreme caution in CHILDREN younger than 6 years old; safety and effectiveness in these children have not been confirmed.

Caution is advised when using Dexchlorpheniramine/Phenylephrine/Methscopolamine Solution in CHILDREN; they may be more sensitive to its effects, especially excitability.

PREGNANCY and BREAST-FEEDING: It is not known if Dexchlorpheniramine/Phenylephrine/Methscopolamine Solution can cause harm to the fetus. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Dexchlorpheniramine/Phenylephrine/Methscopolamine Solution while you are pregnant. Dexchlorpheniramine/Phenylephrine/Methscopolamine Solution is found in breast milk. Do not breast-feed while taking Dexchlorpheniramine/Phenylephrine/Methscopolamine Solution.

Possible side effects of Dexchlorpheniramine/Phenylephrine/Methscopolamine Solution:

All medicines may cause side effects, but many people have no, or minor side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Blurred vision; dizziness; drowsiness; dry mouth, nose, or throat; excitability or irritability (especially in children); giddiness; headache; lightheadedness; loss of appetite; nausea; nervousness; stomach upset; trouble sleeping; unsteadiness; unusual tiredness or weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); fast or irregular heartbeat; fever or sore throat; flushing; hallucinations; mental or mood changes; seizures; severe drowsiness; severe sunburn; shortness of breath; tingling in hands or feet; tremor; unusual bruising or bleeding; vomiting.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch .

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include irregular heartbeat; mental or mood changes (eg, confusion, anxiety); pupil enlargement; seizure; severe dizziness, drowsiness, headache, nausea, or vomiting; tremor; trouble swallowing.

Proper storage of Dexchlorpheniramine/Phenylephrine/Methscopolamine Solution:

Store Dexchlorpheniramine/Phenylephrine/Methscopolamine Solution in a tightly closed container between 68 and 77 degrees F (20 and 25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat and light. Keep Dexchlorpheniramine/Phenylephrine/Methscopolamine Solution out of the reach of children and away from pets.

General information:

If you have any questions about Dexchlorpheniramine/Phenylephrine/Methscopolamine Solution, please talk with your doctor, pharmacist, or other health care provider.

Dexchlorpheniramine/Phenylephrine/Methscopolamine Solution is to be used only by the patient for whom it is prescribed. Do not share it with other people.

If your symptoms do not improve or if they become worse, check with your doctor.

Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Dexchlorpheniramine/Phenylephrine/Methscopolamine Solution. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

More Dexchlorpheniramine/Phenylephrine/Methscopolamine resources

Dexchlorpheniramine/Phenylephrine/Methscopolamine Use in Pregnancy & Breastfeeding
Dexchlorpheniramine/Phenylephrine/Methscopolamine Drug Interactions
Dexchlorpheniramine/Phenylephrine/Methscopolamine Support Group
0 Reviews for Dexchlorpheniramine/Phenylephrine/Methscopolamine - Add your own review/rating

Compare Dexchlorpheniramine/Phenylephrine/Methscopolamine with other medications

Nasal Congestion
Sinus Symptoms

Monday, 26 September 2016

Doculase

Generic Name: docusate (DOK ue sate)

Brand Names: Calcium Stool Softener, Colace, Correctol Softgel Extra Gentle, D-S Caps, Diocto, Doc-Q-Lace, Docu, Docu Soft, Doculase, Docusoft S, DocuSol, DOK, DOS, DSS, Dulcolax Stool Softener, Enemeez Mini, Fleet Sof-Lax, Kao-Tin, Kaopectate Stool Softener, Kasof, Phillips Stool Softener, Silace, Sur-Q-Lax

What is Doculase (docusate)?

Docusate is a stool softener. It makes bowel movements softer and easier to pass.

Docusate is used to treat or prevent constipation, and to reduce pain or rectal damage caused by hard stools or by straining during bowel movements.

Docusate may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about Doculase (docusate)?

You should not use docusate if you are allergic to it, or if you have a blockage in your intestines. Do not use docusate while you are sick with nausea, vomiting, or stomach pain. Do not take mineral oil while using docusate, unless your doctor tells you to.

Ask a doctor or pharmacist before using docusate if you are on a low-salt diet, if you are pregnant or breast-feeding, or if you have recently had a sudden change in your bowel habits lasting for longer than 2 weeks.

What should I discuss with my healthcare provider before using Doculase (docusate)?

Ask a doctor or pharmacist if it is safe for you to take docusate:

if you are on a low-salt diet; or

if you have recently had a sudden change in your bowel habits lasting for longer than 2 weeks.

It is not known whether docusate will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. It is not known whether docusate passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Do not give this medication to a child younger than 2 years old without the advice of a doctor.

How should I use Doculase (docusate)?

Use exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Take docusate tablets or capsules with a full glass of water. Drink plenty of liquids while you are taking docusate. Do not crush, chew, or break a docusate capsule. Swallow it whole.

Measure liquid medicine with a special dose-measuring spoon or medicine cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one. Mix the liquid with 6 to 8 ounces of milk, fruit juice, or infant formula and drink the mixture right away.

Do not take docusate rectal enema by mouth. It is for use only in your rectum. Wash your hands before and after using docusate rectal enema.

Try to empty your bowel and bladder just before using the enema.

Twist off the applicator tip. Lie down on your left side with your knees bent, and gently insert the tip of the enema applicator into the rectum. Squeeze the tube to empty the entire contents into the rectum. Throw away the tube, even if there is still some medicine left in it.

After using docusate, you should have a bowel movement within 12 to 72 hours. Call your doctor if you have not had a bowel movement within 1 to 3 days.

Do not use docusate for longer than 7 days unless your doctor has told you to. Overuse of a stool softener can lead to serious medical problems. Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Since docusate is used as needed, you may not be on a dosing schedule. If you are using the medication regularly, use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include nausea, vomiting or stomach pain.

What should I avoid while using Doculase (docusate)?

Avoid using laxatives or other stool softeners unless your doctor has told you to.

Avoid using the bathroom just after using docusate enema.

Doculase (docusate) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using docusate and call your doctor at once if you have a serious side effect such as:

rectal bleeding or irritation;

numbness or a rash around your rectum;

severe diarrhea or stomach cramps; or

continued constipation.

Less serious side effects may include:

mild diarrhea; or

mild nausea.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Doculase (docusate)?

There may be other drugs that can interact with docusate. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More Doculase resources

Doculase Side Effects (in more detail)
Doculase Use in Pregnancy & Breastfeeding
Doculase Drug Interactions
Doculase Support Group
0 Reviews for Doculase - Add your own review/rating

Docusate Professional Patient Advice (Wolters Kluwer)

Colace MedFacts Consumer Leaflet (Wolters Kluwer)

Diocto Liquid MedFacts Consumer Leaflet (Wolters Kluwer)

Docusate Salts Monograph (AHFS DI)

Dostinex Monograph (AHFS DI)

Enemeez Mini Enema MedFacts Consumer Leaflet (Wolters Kluwer)

Compare Doculase with other medications

Constipation

Where can I get more information?

Your pharmacist can provide more information about docusate.

See also: Doculase side effects (in more detail)

Friday, 23 September 2016

Darvon

Generic Name: propoxyphene (pro POX i feen)

Brand Names: Darvon, Darvon-N

What is Darvon (propoxyphene)?

Propoxyphene was withdrawn from the U.S. market in November 2010.

Propoxyphene is in a group of drugs called narcotic pain relievers.

Propoxyphene is used to relieve mild to moderate pain.

Propoxyphene may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about Darvon (propoxyphene)?

Propoxyphene was withdrawn from the U.S. market in November 2010.

Do not use this medication if you have a history of suicidal thoughts or actions. Propoxyphene should never be taken together with a sedative (such as Valium or Xanax) or an antidepressant if you are also drinking large amounts of alcohol. Propoxyphene may be habit-forming and should be used only by the person it was prescribed for. Keep the medication in a secure place where others cannot get to it. Do not drink alcohol while you are taking propoxyphene. Dangerous side effects or death can occur when alcohol is combined with a narcotic pain medicine. Check your food and medicine labels to be sure these products do not contain alcohol. Never take more than your prescribed dose of propoxyphene. Tell your doctor if the medicine seems to stop working as well in relieving your pain. Propoxyphene can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert. Do not stop using propoxyphene suddenly, or you could have unpleasant withdrawal symptoms. Talk to your doctor about how to avoid withdrawal symptoms when stopping the medication.

What should I tell my healthcare provider before taking Darvon (propoxyphene)?

If you have any of these other conditions, you may need a dose adjustment or special tests:

asthma, COPD, sleep apnea, or other breathing disorders;

liver or kidney disease;

a history of head injury or brain tumor;

mental illness; or

a history of drug or alcohol addiction.

FDA pregnancy category C. This medication may be harmful to an unborn baby, and could cause breathing problems or addiction/withdrawal symptoms in a newborn. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Propoxyphene passes into breast milk and could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Older adults may be more sensitive to the effects of this medicine.

How should I take Darvon (propoxyphene)?

Take this medication exactly as it was prescribed for you. Never take propoxyphene in larger amounts, or use it for longer than recommended by your doctor. Follow the directions on your prescription label. Tell your doctor if the medicine seems to stop working as well in relieving your pain.

Take each dose with a full glass of water. Take propoxyphene with food or milk if it upsets your stomach. Do not stop using propoxyphene suddenly, or you could have unpleasant withdrawal symptoms. Talk to your doctor about how to avoid withdrawal symptoms when stopping the medication. Store propoxyphene at room temperature away from moisture and heat. Keep track of the amount of medicine used from each new bottle. Propoxyphene is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.

What happens if I miss a dose?

Since propoxyphene is taken as needed, you may not be on a dosing schedule. If you are taking the medication regularly, take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of propoxyphene can be fatal, especially if you are also drinking alcohol or taking a sedative or antidepressant.

Overdose symptoms may include extreme drowsiness, pinpoint or dilated pupils, confusion, cold and clammy skin, blue lips, weak pulse, slow or uneven heart rate, shallow breathing, fainting, or breathing that stops.

What should I avoid while taking Darvon (propoxyphene)?

Do not drink alcohol. Dangerous side effects or death can occur when alcohol is combined with a narcotic pain medicine. Check your food and medicine labels to be sure these products do not contain alcohol. Propoxyphene may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Grapefruit and grapefruit juice may interact with propoxyphene and lead to potentially dangerous effects. Discuss the use of grapefruit products with your doctor. Do not increase or decrease the amount of grapefruit products in your diet without first talking to your doctor.

Darvon (propoxyphene) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any of these serious side effects:

shallow breathing, slow heartbeat;

feeling light-headed, fainting;

confusion, hallucinations, unusual thoughts or behavior;

seizure (convulsions); or

jaundice (yellowing of the skin or eyes).

Less serious side effects include:

feeling dizzy or drowsy;

nausea, vomiting, stomach pain, constipation;

headache, muscle pain;

blurred vision; or

mild skin rash.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Darvon (propoxyphene)?

Do not take propoxyphene with other narcotic pain medications, sedatives, tranquilizers, muscle relaxers, or other medicines that can make you sleepy or slow your breathing. Dangerous side effects may result.

Tell your doctor about all other medicines you use, especially:

amiodarone (Cordarone, Pacerone);

aprepitant (Emend);

bosentan (Tracleer);

conivaptan (Vaprisol);

dexamethasone (Decadron, Hexadrol);

imatinib (Gleevec);

isoniazid (for treating tuberculosis);

St. John's wort;

an antibiotic such as clarithromycin (Biaxin), dalfopristin/quinupristin (Synercid), erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin), rifampin (Rifadin, Rifater, Rifamate), or telithromycin (Ketek);

antifungal medication such as clotrimazole (Mycelex Troche), fluconazole (Diflucan), itraconazole (Sporanox), ketoconazole (Nizoral), or voriconazole (Vfend);

an antidepressant such as nefazodone;

a barbiturate such as butabarbital (Butisol), secobarbital (Seconal), pentobarbital (Nembutal), or phenobarbital (Solfoton);

a blood thinner such as warfarin (Coumadin);

heart or blood pressure medication such as diltiazem (Cartia, Cardizem), felodipine (Plendil), nifedipine (Nifedical, Procardia), verapamil (Calan, Covera, Isoptin, Verelan), and others;

HIV/AIDS medicine such as atazanavir (Reyataz), delavirdine (Rescriptor), efavirenz (Sustiva), etravirine (Intelence), fosamprenavir (Lexiva), indinavir (Crixivan), nelfinavir (Viracept), nevirapine (Viramune), saquinavir (Invirase), or ritonavir (Norvir);

medicines to treat narcolepsy, such as armodafanil (Nuvigil) or modafanil (Progivil); or

seizure medication such as carbamazepine (Carbatrol, Tegretol), felbamate (Felbatol), oxcarbazepine (Trileptal), or phenytoin (Dilantin), or primidone (Mysoline).

This list is not complete and other drugs may interact with propoxyphene. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More Darvon resources

Darvon Side Effects (in more detail)
Darvon Use in Pregnancy & Breastfeeding
Drug Images
Darvon Drug Interactions
Darvon Support Group
3 Reviews for Darvon - Add your own review/rating

Darvon Prescribing Information (FDA)

Darvon MedFacts Consumer Leaflet (Wolters Kluwer)

Darvon Advanced Consumer (Micromedex) - Includes Dosage Information

Propoxyphene Professional Patient Advice (Wolters Kluwer)

Darvon-N Prescribing Information (FDA)

Propoxyphene Hydrochloride Monograph (AHFS DI)

Compare Darvon with other medications

Pain

Where can I get more information?

Your pharmacist can provide more information about propoxyphene.

See also: Darvon side effects (in more detail)

Thursday, 22 September 2016

Dapsone topical

Class: Skin and Mucous Membrane Agents, Miscellaneous
ATC Class: D10AX05
Chemical Name: Diaminodiphenylsulfone
Molecular Formula: C₁₂H₁₂N₂O₂S
CAS Number: 80-08-0
Brands: Aczone

Introduction

Synthetic sulfone¹ ² ³ ⁵ ¹⁸ with anti-infective and anti-inflammatory effects.² ³ ⁵ ¹⁸

Uses for Dapsone

Acne Vulgaris

Topical treatment of acne vulgaris.¹ ² ³ ⁴ ¹¹

Effective against inflammatory acne lesions and, to a lesser extent, noninflammatory acne lesions.² ³

Dapsone Dosage and Administration

Administration

Topical Administration

Administer topically to the skin as a 5% gel.¹

For external use only.¹ Do not use orally or intravaginally; avoid contact with the mouth and eyes.¹

Gently cleanse and dry the acne-affected area prior to application.¹ Apply a pea-sized amount of dapsone 5% gel in a thin layer; rub in gently and completely.¹

The gel is gritty with visible drug substance particles.¹ Wash hands after applying the gel.¹

Dosage

Pediatric Patients

Acne Vulgaris

Topical

Children ≥12 years of age: Apply a thin layer of dapsone 5% gel to cleansed affected area twice daily.¹

Reassess use of the drug if improvement does not occur after 12 weeks of treatment.¹

Has been used for up to 12 months in clinical studies.³

Adults

Acne Vulgaris

Topical

Apply a thin layer of dapsone 5% gel to the cleansed affected area twice daily.¹

Reassess use of the drug if improvement does not occur after 12 weeks of treatment.¹

Has been used for up to 12 months in clinical studies.³

Cautions for Dapsone

Contraindications

Manufacturer states none known.¹

Warnings/Precautions

Sensitivity Reactions

Moderate erythema has been reported when topical dapsone 5% gel was evaluated in combined contact sensitization/irritation studies.¹ Pruritus,² ³ ⁶ rash,³ and contact dermatitis⁶ were reported in some patients receiving the topical gel for treatment of acne vulgaris.

Oral dapsone has been associated with hypersensitivity reactions that include severe dermatologic reactions.¹ ⁷ ¹⁶ (See Dermatologic Reactions under Cautions.) Hypersensitivity reactions reported with oral dapsone have also included fever, malaise, hepatitis, and hemolysis.¹⁰

Topical dapsone did not induce phototoxicity or photoallergy in human dermal safety studies.¹

Hematologic Effects

Oral dapsone has been associated with dose-related hemolysis and hemolytic anemia.¹ ¹⁴ Agranulocytosis also reported in patients receiving oral dapsone.¹ ⁹ Individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency are more prone to hemolysis when receiving certain drugs.¹ G6PD deficiency is most prevalent in populations of African, South Asian, Middle Eastern, and Mediterranean ancestry.¹

There were no reports of clinically relevant hemolysis or hemolytic anemia in clinical studies evaluating topical dapsone 5% gel in individuals with acne vulgaris, including individuals with G6PD deficiency.¹ ² ³ ⁶ However, laboratory changes suggestive of hemolysis (slight decreases in hemoglobin) occurred in some individuals with G6PD deficiency using the topical gel.¹ ² ⁶

If signs and symptoms suggestive of hemolytic anemia occur, discontinue topical dapsone therapy.¹

Because of the potential for hemolytic reactions, do not use topical dapsone 5% gel in individuals receiving oral dapsone or antimalarial agents.¹ (See Specific Drugs under Interactions.)

Concomitant use of topical dapsone 5% gel and co-trimoxazole may increase the risk of hemolysis in patients with G6PD deficiency.¹ (See Specific Drugs under Interactions.)

Peripheral Neuropathy

Oral dapsone has been associated with peripheral neuropathy (motor loss and muscle weakness).¹

Peripheral neuropathy was not reported in clinical studies evaluating topical dapsone 5% gel for the treatment of acne vulgaris.¹

Dermatologic Reactions

Oral dapsone has been associated with serious skin reactions, including toxic epidermal necrolysis, erythema multiforme, morbilliform and scarlatiniform reactions, bullous and exfoliative dermatitis, erythema nodosum, and urticaria.¹ ⁷

Although erythema,¹ pruritus,² ³ and rash³ were reported in clinical studies evaluating topical dapsone 5% gel for the treatment of acne vulgaris, more severe dermatologic reactions were not reported.¹

Specific Populations

Pregnancy

Category C.¹

Oral dapsone has been associated with embryocidal effects in rats and rabbits when used in dosages approximately 800 and 500 times, respectively, the systemic exposure (based on AUC) observed in human females receiving the maximum recommended dosage of topical dapsone 5% gel.¹ These effects were probably secondary to maternal toxicity.¹

Use during pregnancy only if potential benefits outweigh potential risks to the fetus.¹

Lactation

Distributed into milk following oral administration.¹ Systemic absorption is low following topical application of dapsone 5% gel; however, because of the potential to cause adverse reactions in nursing infants, discontinue nursing or discontinue topical dapsone therapy.¹

Pediatric Use

Safety and efficacy not established in children <12 years of age.¹

Geriatric Use

Insufficient experience with topical dapsone 5% gel in geriatric patients ≥65 years of age to determine whether such individuals respond differently than younger individuals.¹

Common Adverse Effects

Local reactions at the application site (oiliness/peeling, dryness, erythema).¹ ²

Interactions for Dapsone

Although only small amounts of dapsone are absorbed systemically following topical application to skin, the possibility that drug interactions could occur should be considered.¹ Concomitant use of oral dapsone and certain drugs (e.g., rifampin, anticonvulsants, St. John's wort) may increase the formation of dapsone hydroxylamine, a dapsone metabolite associated with hemolysis.¹ In addition, concomitant use of oral dapsone and folic acid antagonists (e.g., pyrimethamine) may increase the likelihood of adverse hematologic effects.¹

Specific Drugs

Drug	Interaction	Comments
Antimalarial agents	Increased risk of hemolytic reactions if topical dapsone used concomitantly with antimalarial agents¹	Do not use topical dapsone in patients receiving antimalarial agents¹
Benzoyl peroxide	In vitro, combinations of topical dapsone 5% gel and topical benzoyl peroxide resulted in an orange discoloration¹⁷ Concomitant use of topical dapsone 5% gel and topical benzoyl peroxide in individuals with acne vulgaris may result in temporary local yellow or orange discoloration of the skin and facial hair;¹ usually resolves in 4–57 days¹
Co-trimoxazole	Concomitant use of topical dapsone 5% gel and oral co-trimoxazole results in increased systemic exposure to dapsone and dapsone metabolites; pharmacokinetics of co-trimoxazole not affected¹ ⁵ Possible increased risk of hemolysis in patients with G6PD deficiency¹
Dapsone, oral	Increased risk of hemolytic reactions if oral and topical dapsone used concomitantly¹	Do not use topical dapsone in patients receiving oral dapsone¹

Dapsone Pharmacokinetics

Absorption

Bioavailability

Absorbed systemically following topical application to skin.¹ ⁵

In patients with acne vulgaris skin lesions, plasma concentrations of dapsone are detectable within 2 hours after the first dose of topical dapsone 5% gel.⁵

After topical application of dapsone 5% gel to acne vulgaris skin lesions on the face, upper back, shoulders, and/or upper chest (up to approximately 22.5% of total body surface area) twice daily for 14 days, mean peak plasma concentrations of the drug were 19.4 ng/mL and the median time to peak concentrations after a dose was 9 hours.⁵

In a long-term safety study of dapsone 5% gel, there was no evidence that systemic exposure increases over time.¹

Systemic exposure (AUC) following a 14-day regimen of dapsone 5% gel is 126 times lower than systemic exposure (AUC) following a single 100-mg dose of oral dapsone.⁵

Special Populations

Systemic dapsone exposure following topical application of dapsone 5% gel in children 12–15 years of age is similar to that reported in those ≥16 years of age.¹

Stability

Storage

Topical

Gel

20–25°C (may be exposed to 15–30°C).¹ Do not freeze.¹

ActionsActions

Synthetic sulfone¹ ² ³ ⁵ ¹⁸ with anti-infective and anti-inflammatory effects.³ ⁵ ¹⁸

For dermatologic use, dapsone is commercially available in an aqueous gel base.¹

Mechanism of action in the treatment of acne vulgaris not known, but may result from a combination of both anti-inflammatory and anti-infective effects.¹ ² ³ ¹⁸

Dapsone exerts a variety of anti-inflammatory effects.² ³ ¹⁸ The drug may inhibit myeloperoxidase- and hydrogen peroxide-based cytotoxic systems in neutrophils or may act as a scavenger of reactive oxygen species, thereby minimizing inflammation associated with generation of these reactive species.¹⁸

The anti-infective effects of dapsone involve inhibition of folic acid synthesis in susceptible organisms.¹⁸

In vitro, dapsone has some antibacterial activity against Propionibacterium acnes.¹⁸ It is not known whether topical dapsone therapy results in decreased susceptibility of P. acnes to other drugs used to treat acne.¹

Advice to Patients

Importance of using as directed by the clinician and only for condition prescribed.¹

Advise patient that topical dapsone is for external use only and should not be used orally or intravaginally; importance of avoiding contact with the mouth and eyes.¹

Importance of storing at room temperature and protecting the drug from freezing.¹

Importance of informing clinician of glucose-6-phosphate dehydrogenase (G6PD) deficiency.¹

Importance of reporting any signs of adverse reactions to a clinician.¹

Importance of informing clinician of existing or contemplated concomitant therapy, including prescription and OTC drugs, especially topical agents applied to the skin (e.g., preparations containing benzoyl peroxide).¹

Importance of women informing clinicians if they are or plan to become pregnant or plan to breast-feed.¹

Importance of informing patients of other important precautionary information.¹ (See Cautions.)

Preparations

Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details.

Dapsone
Routes	Dosage Forms	Strengths	Brand Names	Manufacturer
Topical	Gel	5%	Aczone	Allergan

Disclaimer

This report on medications is for your information only, and is not considered individual patient advice. Because of the changing nature of drug information, please consult your physician or pharmacist about specific clinical use.

The American Society of Health-System Pharmacists, Inc. and Drugs.com represent that the information provided hereunder was formulated with a reasonable standard of care, and in conformity with professional standards in the field. The American Society of Health-System Pharmacists, Inc. and Drugs.com make no representations or warranties, express or implied, including, but not limited to, any implied warranty of merchantability and/or fitness for a particular purpose, with respect to such information and specifically disclaims all such warranties. Users are advised that decisions regarding drug therapy are complex medical decisions requiring the independent, informed decision of an appropriate health care professional, and the information is provided for informational purposes only. The entire monograph for a drug should be reviewed for a thorough understanding of the drug's actions, uses and side effects. The American Society of Health-System Pharmacists, Inc. and Drugs.com do not endorse or recommend the use of any drug. The information is not a substitute for medical care.

References

1. Allergan. Aczone (dapsone) gel 5% prescribing information. Irvine, CA. 2009 Mar.

2. Draelos ZD, Carter E, Maloney JM et al. Two randomized studies demonstrate the efficacy and safety of dapsone gel, 5% for the treatment of acne vulgaris. J Am Acad Dermatol. 2007; 56:439.e1-10.

3. Lucky AW, Maloney JM, Roberts J et al. Dapsone gel 5% for the treatment of acne vulgaris: safety and efficacy of long-term (1 year) treatment. J Drugs Dermatol. 2007; 6:981-7. [PubMed 17966175]

4. Raimer S, Maloney JM, Bourcier M et al. Efficacy and safety of dapsone gel 5% for the treatment of acne vulgaris in adolescents. Cutis. 2008; 81:171-8. [PubMed 18441772]

5. Thiboutot DM, Willmer J, Sharata H et al. Pharmacokinetics of dapsone gel, 5% for the treatment of acne vulgaris. Clin Pharmacokinet. 2007; 46:697-712. [PubMed 17655376]

6. Piette WW, Taylor S, Pariser D et al. Hematologic safety of dapsone gel, 5%, for topical treatment of acne vulgaris. Arch Dermatol. 2008; 144:1564-70. [PubMed 19075138]

7. Agrawal S, Agarwalla A. Dapsone hypersensitivity syndrome: a clinico-epidemiological review. J Dermatol. 2005; 32:883-9. [PubMed 16361748]

9. Coleman MD. Dapsone-mediated agranulocytosis: risks, possible mechanisms and prevention. Toxicology. 2001; 162:53-60. [PubMed 11311458]

10. Corp CC, Ghishan FK. The sulfone syndrome complicated by pancreatitis and pleural effusion in an adolescent receiving dapsone for treatment of acne vulgaris. J Pediatr Gastroenterol Nutr. 1998; 26:103-5. [PubMed 9443128]

11. Del Rosso JQ. Newer topical therapies for the treatment of acne vulgaris. Cutis. 2007; 80:400-10. [PubMed 18189027]

14. Ismail R. Acne fulminans with dapsone induced haemolysis: a case report. Med J Malaysia. 1987; 42:124-6. [PubMed 2971861]

16. Tomecki KJ, Catalano CJ. Dapsone hypersensitivity. The sulfone syndrome revisited. Arch Dermatol. 1981; 117:38-9. [PubMed 6450569]

17. Dubina MI, Fleischer AB. Interaction of topical sulfacetamide and topical dapsone with benzoyl peroxide. Arch Dermatol. 2009; 145:1027-9. [PubMed 19770443]

18. Center for Drug Evaluation and Research. Microbiology review of NDA application 21-794. 2005 Jun 20.

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